Research Studies

The study on functioning of Health & Family Welfare Societies was proposed by Sector Investment Programme Office (SIPO), Directorate General of Health Services, Govt. of Haryana, Panchkula to National Institute of Health & Family Welfare in January 2007 with the objective to study the major activities undertaken by the District Health & Family Welfare Societies and SKS at facility levels under health sector reforms in the State. In all, 4 Districts, 4 CHCs, 8 PHCs, 16 Sub-centres, 32 Villages, 64 FGDs and 643 patients from various health facilities were visited and evaluation conducted as per objectives of the study given by SIPO

Title

STUDY OF VARIOUS ETIOLOGIES IN COUPLES HAVING REPEATED PREGNANCY LOSS WITH SPECIAL REFERENCE TO MALE FACTOR

Investigators

Principal Investigator: Dr. M.M. Misro, Reader, Dept. of RBM (after Dr. Kusum Chopra, Reader, superannuated);Co-Investigators:Dr.Pikee Saxena, Lecturer,Dept. of RBM,Dr.D.Sinha,Dr. Gyan Singh;Project Advisor: Prof. Somnath Roy, Ex-Director,NIHFW

Year

2006

Department

RBM,Department of E & T

Sponsoring Agency

Keywords

ETIOLOGIES,COUPLES,PREGNANCY,MALE,FACTOR

Abstract

The commonest female factor in our study was endocrinological factor 39 (52.0%) followed by infective pathology 38 (50.6%), anatomical 30 (40.0%) and immunological 30 (12.0%) factor. All patients had normal karyotype. Although tubal factor is not a direct cause of RPL, it signifies previous infections or may occur due to previous interventions. The commonest factor associated with male partners of RPL group was infection 23 (30.6%) followed by anatomical 3 (4%), genetic 1 (1.3%) and immunological 1 (1.3%) factors.

Title

Evaluation of the Effects of various Intervention Strategies to Counteract Damages Induced in the Testis Due to Cryptorchildism:Studies in Rats

Investigators

Principal Investigator:Dr.M.M.Misro,Reader,Dept of RBM;Co-Investigator:Mr.Mukesh Kumar,SRF ICMR

Year

2006

Department

RBM

Sponsoring Agency

Keywords

EVALUATION,,INTERVENTION ,TESTIS,CRYPTORCHILDISM,RATS

Abstract

The adverse effects of cryptorchidism on spermatogenesis and the increase in the oxidative stress parameters was established in rats made cryptorchid for 1, 6, 7 , 15 and 30 days. Following the non-invasive method of cryptorchidism the severity of the affect was seen more pronounced only after 30 days of cryptorchidism. Therefore, the intervention strategies were initiated in after 30 days of cryptorchidism. Lipid peroxidation in the testicular tissue was seen significantly altered after 15 and 30 days of cryptorchidism. However, with exogenous interventions of either hCG, vitamin C or vitamin E, the lipid peroxidation in the testicular was observed to be significantly lowered. This was supported by an upward trend in the testicular weight in those groups of animals receiving the interventions alone. No other interventions had demonstrated similar benefits in the reduction of lipid peroxidation or increase in testicular weight. The studies are promising, but more in-depth studies and confirmatory trials in a different species of animals are necessary before pre-clinical or clinical trials are initiated with these exogenous treatments.

Title

Evaluation of Efficacy,Safety and Reversibility of a Potential Male Hormonal Contraceptive Regimen Using Dienogest(STS 557) Plus Testosterone Undeconoate in Albino Rats

Investigators

Principal Investigator:Dr.M.M.Misro,Reader,Dept of RBM;Co-Investigator:Dr.S.P.Chaki, ARO;Expert Consultant: Prof. Somnath Roy, Ex-Director,NIHFW Dr.S.P.Chaki, ARO;Expert Consultant: Prof. Somnath Roy, Ex-Director,

Year

2006

Department

RBM

Sponsoring Agency

Keywords

CONTRACEPTIVE,EFFICACY,SAFETY,REVERSIBILITY,MALE,HORMONAL,DIENOGEST,S,TESTOSTERONE,UNDECONOATE,ALBINO,RATS

Abstract

The present studies have confirmed once again that a progestin and long-acting testosterone combination constitutes the best alternative method of contraception in the male. Progestin DNG, 40 mg/kg b.w + TU 25 mg/kg b.w was found out as the best and most effective combination in terms of contraceptive efficacy. With this dose combination the frequency of drug administration was restricted to only once a month injection for DNG and once every 6 weeks for TU. In mating studies, none of the females mated with treated males produced any offsprings. Withdrawal of treatment after 60 day and 120 days restored complete spermatogenesis and counts and motility of spermatozoa in the epididymis were completely restored. Germ cell apoptosis was more frequent in the seminiferous epithelium of rats receiving the DNG +TU combination treatment compared to vehicle control or other treatment groups. Both drugs are already in use in humans. However, in the combination treatment studies, toxicity parameters during the treatment and withdrawal period revealed insignificant alterations compared to control values. This development has the potential of developing a monthly injectable contraceptive for the male. Attempts are being made to patent the effective dose combination that provided 100% contraceptive effect. Further studies in higher animals are warranted before the combination is put for clinical trials.

Title

An Operations Research Study To Increase Public-Private Partnership Under Revised National Tuberculosis Control Programme (RNTCP) In Urban Areas - Phase I

Investigators

Principal Investigator:Dr V. K. Tiwari,Reader & Acting Head,Deptt. of P&E;Co-Investigators:Dr. U. Datta, Reader, Deptt. of E&T,Mr. J.P.Shivdasani, RO, Deptt. of P&E,Ms. Reeta Dhingra, RO, Deptt. of P&E,Dr. Rachna Agarwal,ARO,Deptt. of MCHA

Year

2005

Department

Deptt. of P&E, Deptt. of E&T, Deptt. of MCHA

Sponsoring Agency

Central T.B. Division, MOHFW and State TB Society,Gov. Of Rajasthan

Keywords

Public-Private Partnership,Revised National Tuberculosis Control Programme,Private practitioners Involvement in RNTCP

Abstract

General Objective:To increase participation of private practitioners (PPs) under Revised National Tuberculosis Control Programme (RNTCP) in urban areas. Specific Objectives for Phase I (Pre intervention):1.To conduct situational analysis regarding involvement of PPs under RNTCP 2.To study the perspectives of stakeholders regarding diagnosis & treatment facilities under RNTCP

Title

A Pilot Study On Communication Strategy For Reaching The Unreached Tribal Population In Mandla District Of Madhya Pradesh

Investigators

Dr. T. Mathiyazhagan, Prof. & Head, Deptt. of Communication

Year

2005

Department

Deptt. of Communication

Sponsoring Agency

Keywords

Communication Strategy, Tribal Population, Messages, Interpersonal Communication, Mass Media

Abstract

General Objective: The overall objective of the study is to ‘design an appropriate communication strategy to reach the un-reached tribal population with health care messages for improving the health status of tribals in Mandla district of Madhya Pradesh. Specific Objectives: 1. To understand the level of knowledge and perceptions of the tribals about the health care delivery services available to them in their state. 2. To assess the basic communication and other infrastructural facilities available in the study area for carrying out communication/IEC activities for the benefit of the tribals. 3. To list out the major sources of information available to the tribals in their state. 4. To study the most preferred sources of information by the tribals and the reasons thereof. 5. To analyse the existing pattern of percolation of messages among the tribals in the study area. 6. To develop an appropriate communication package to reach the unreached tribal population with health care messages in Mandla district of Madhya Pradesh.

Title

A Study On Identification Of Training Needs & Designing Curriculum Of Nss Volunteers For Creating Community Awareness On Population Stabilization

Investigators

Dr. Neera Dhar, Reader, Deptt. of E&The

Year

2004

Department

Deptt. of E&The

Sponsoring Agency

Keywords

Training Needs, Curriculum, NSS Volunteers, Community Awareness, Population Stabilization

Abstract

General Objective: To identify training needs of NSS volunteers and design a more relevant and meaningful training curriculum for creating community awareness on population stabilization in the country. Specific Objectives: 1. To identify knowledge & skills of NSS volunteers regarding population stabilization in the country 2. To design training curriculum in the area of population stabilization

Title

Review Study on National Health Information System in Two States of India

Investigators

Dr. V.K. Tiwari, Reader

Year

2004

Department

Deptt. of P&E

Sponsoring Agency

Keywords

Abstract

To study, document and critically examine the National Health Information System at various levels and to make recommendations for an efficient Health Information System.

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